We have written this post for informational purposes only, and our goal is solely to inform people about the science behind memantine’s effects, mechanisms, and current medical uses. Week 1: 5 mg orally once a day. The most commonly reported side effects of memantine include constipation, nausea, and headache. 43% of those users who reviewed Memantine reported a positive effect, while 41% reported a negative effect. Therefore, it is important to take all of the information below with a healthy grain of salt! These factors include: individual variation, dosage, time span over which you’ve taken the drug, and whether you’re taking any other drugs or supplements. Common side effects include headache, constipation, sleepiness, and dizziness. Remission was defined as an HAM-A total score ≤7. It is important to note that memantine and other Alzheimer’s drugs do not cure Alzheimer’s – they only slow some of the cognitive decline commonly seen in this disease. A pilot open label prospective study of memantine monotherapy in adults with ADHD. We will be providing unlimited waivers of publication charges for accepted research articles as well as case reports and case series related to COVID-19. ABSTRACT Objective Review the evidence on the efficacy of memantine in the treatment of the anxiety disorders. -Initial Dose: 7 mg orally once a day. All of our content is written by scientists and people with a strong science background. Glutamate, an excitatory neurotransmitter in the central nervous system (CNS), may play a role in the development of anxiety. The important (much rarer) side effects, which caregivers should watch for because of how memantine impacts signals in the brain, are shortness of … Although this effect has not been studied directly in humans, at least one animal study has reported that treating mice with memantine after they experienced repetitive mild traumatic brain injury showed less extensive damage to their brains compared to controls [34]. Future investigations would benefit from placebo-controlled clinical trials to further investigate the true benefits of memantine for the treatment of anxiety. There is some evidence memantine may be helpful in dealing with anxiety disorders. 15 consecutive partially responding anxious patients were treated with adjunctive memantine for 10 weeks. Its use in other illnesses such as bipolar disorder and autism is currently being explored. It is a primarily known for being a drug treatment for nerve pain as well as being an anticonvulsant, or epileptic drug. Memantine was not more effective at reducing muscle spasms in MS patients than placebo [42]. Clinical trials typically use somewhere between 5-40mg per day, often administered in two equal doses spread over the course of the day. Memantine partially inhibits N-methyl-D-aspartate (NMDA) glutamate receptors thus dampening synaptic glutamate availability [10]. Memantine is used to treat the symptoms of Alzheimer's disease (AD; a brain disease that slowly destroys the memory and the ability to think, learn, communicate and handle daily activities). Objective. Animal reproduction studies have shown adverse events, and patients are advised to use memantine with caution before- or during pregnancy [3]. Furthermore, memantine caused short-term worsening of neurologic symptoms in MS, thereby exacerbating the cognitive deficits [41]. This may be due to the fact that it lowers glutamate levels, which is often implicated in anxiety. Mean outcome trajectories were assessed by implementing a random intercept model to account for the within subject dependency due to assessments over the study period (Figure 1). One case study of a bipolar patient resistant to conventional treatment reported that 10 mg/day of memantine for 4 weeks resulted in a complete disappearance of manic symptoms [20]. It gives you genetic-based diet, lifestyle and supplement tips that can help improve your cognitive function. We are committed to sharing findings related to COVID-19 as quickly as possible. Although memantine has a number of relatively well-supported medical uses when administered by qualified medical professionals, there are a number of factors that doctors may look for that might disqualify someone from receiving memantine treatment (due to elevated risk of negative side-effects or other adverse reactions). Glutamate, an excitatory neurotransmitter in the central nervous system (CNS), may play a role in the development of anxiety. One of the most common “off-label” uses of memantine is to treat other (i.e. male and female outpatients aged 18–65 with a DSM-IV diagnosis of either generalized or social anxiety disorder based on MINI diagnostic interview; rating of at least “moderately ill” (score of 4) on the Clinical Global Impressions of Severity (CGI-S) scale and score of at least 10 on HAM-A and 5 on HADS anxiety subscale; failure to respond adequately to trial of conventional anxiolytic; adequate treatment duration was considered 4 weeks at therapeutic dose; adequate response is defined as an improvement of ≥50% in symptoms of anxiety on current anxiolytic therapy, as measured subjectively by patients or objectively by physician; stable on current psychiatric medication for ≥6 weeks prior to study entry. This condition often occurs in patients with multiple sclerosis (MS) and can be distressing. Thomas L. Schwartz, Umar A. Siddiqui, Shafi Raza, "Memantine as an Augmentation Therapy for Anxiety Disorders", Case Reports in Psychiatry, vol. Nine patients (60%) were mild to moderately ill, while 6 patients (40%) were markedly ill at the baseline visit according to the CGI scale. According to one study, sixty patients who took memantine daily for their migraines had an average of 3.4 fewer migraines per month, whereas the placebo group only had 1 less per month [28]. Some guidelines recommended to start patients off at 5mg once daily, and increase (“titrate”) the dose in increments of 5mg every week until reaching a dose of 20mg per day [13, 1, 44]. At this point, adding memantine to Ms. A’s regimen of clomipramine (300 mg/day) and sulpiride (400 mg/day) was suggested, and she signed informed consent after explanation of this off-label therapy. Memantine was largely well-tolerated and associated with improvement in ADHD symptoms and neuropsychological performance. Another study reported that 89% of the patients who received memantine along with conventional treatments resolved their OCD symptoms after eight weeks [24]. Memantine has been a godsend for my social anxiety. Listing a study does not mean it has been evaluated by the U.S. Federal Government. Twelve weeks of memantine was reported to slightly decrease anxiety in 7 patients with GAD [22, 23]. Memantine is a medication used to treat moderate-to-severe Alzheimer's disease. Another case study of a bipolar patient hospitalized with mania and depression reported that 20 mg/day of memantine for 10 weeks partially improved mood, anxiety, and sleep quality [21]. For example, an open-label pilot study in 33 bipolar disorder patients hospitalized for mania reported that 21 days of memantine reduced symptoms of mania [19]. Over the years many people have toyed with it hoping to use it to abuse recreational drugs and not develop tolerance, this backfired obviously. Objective. Memantine was initiated at 5 mg/d. This GABA-glutamate balance (when GABA is low and Glutamate is normal to high) is also felt to play a role in the development of generalized or social anxiety disorders. If you’re taking Namenda, there are many factors that may be influencing both the severity and number of side effects that you experience. Joe Cohen won the genetic lottery of bad genes. We believe that the most accurate information is found directly in the scientific source. Copyright © 2012 Thomas L. Schwartz et al. Memantine has a small beneficial effect in people with moderate-to-severe AD. All patients were treated previously with adequate doses of approved selective serotonin reuptake inhibitors (SSRIs). Most notably for trying to the higher and … Result. Selective serotonin re-uptake inhibitor (SSRI), W. E. Narrow, D. S. Rae, L. N. Robins, and D. A. Regier, “Revised prevalence estimates of mental disorders in the United States: using a clinical significance criterion to reconcile 2 surveys' estimates,”, J. C. Ballenger, “Current treatments of the anxiety disorders in adults,”, T. L. Schwartz, N. Azhar, J. Husain et al., “An open-label study of tiagabine as augmentation therapy for anxiety,”, B. M. Cortese and K. L. Phan, “The role of glutamate in anxiety and related disorders,”, C. J. Swanson, M. Bures, M. P. Johnson, A. M. Linden, J. Overall, it is well tolerated in those with moderate--to-severe AD, but it may cause dizziness in a few of the people taking it. May not be central to the brain and others is memantine for anxiety I believe is helping my anxiety and... B in the CNS there are just five medications – including memantine – which have been approved for the time!, etc. HAD-A dropped from baseline value of 13.2 to 8.4 the NPI score 5.8±4.3! 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